Drug—drug interactions resulting from inhibition of cytochrome P450s

Evaluating Pharmacokinetic Drug-Drug Interactions Due to Time-Dependent Inhibition of Cytochrome P450s

The Cytochrome P450s

* Author for correspondence: Fatma M.A. El-garj, School of Distance Education, Universiti Sains Malaysia, 11800 Penang, Malaysia. Email [email protected]. Abstract. Cytochrome P450 monooxygenases are versatile biocatalysts that incorporate oxygen into an enormous range of molecules. The cytochrome P450 proteins are involved in the catalysis of different reactions and these properties have bee...

Cytochrome P450s and chemoprevention.

The cytochrome P450 mono-oxygenase system represents a major defence against chemical challenge from the environment, constituting part of an adaptive response mounted by an organism following exposure to harmful agents. Cytochrome P450s are also able to catalyse the activation of compounds to toxic products, and participate in a variety of essential 'housekeeping' functions, such as biosynthes...

A world of cytochrome P450s.

The world we live in is a biosphere influenced by all organisms who inhabit it. It is also an ecology of genes, with some having rather startling effects. The premise put forth in this issue is cytochrome P450 is a significant player in the world around us. Life and the Earth itself would be visibly different and diminished without cytochrome P450s. The contributions to this issue range from ev...

Extrahepatic cytochrome P450s – relation to cancer susceptibility

Cytochrome P450 (CYP) enzymes in extrahepatic tissues may play important roles in regulating the capacity of individual cells to metabolize environmental carcinogens and hormones. In this thesis, we characterized the cytochrome P450 profile of the human normal breast and investigated whether polymorphisms in the genes encoding the estrogen metabolizing enzymes CYP1B1 and Catechol-O-methyltransf...